The overuse of refined sugar or other nutrients with high glycemic index should be revised to guarantee that nor a single problem could arise from it. An available technique seems to know the usual times in which glucose peaks occur, so the user can wait a certain period.
It's usually said that the peaks for a healthy person are between half hour and two hours. It's then safer to not overload the system creating higher glucose peaks.
The problems that are related with glucose aren't always from genetic factors but the intake of it and the methodology of life. So with sport, or also intellectual exercises that demand glucose —the well known fuel of the brain with also oxygen— for sure the potential risk must be lesser. The same with the use of other techniques that are available from the own nutrition.
Refined sugars aren't recommended in any situation, nor obviously any product that includes them.